Synthesis of α-fluoro-β-hydroxy esters by an enantioselective Reformatsky-type reaction.
نویسندگان
چکیده
The first enantioselective Reformatsky-type reaction of ethyl iodofluoroacetate has been accomplished with alkyl aryl ketones. High diastereoselectivities and excellent enantioselectivities for the major diastereomer (93-95% ee) were achieved with large alkyl groups. For smaller alkyl groups the diastereoselectivities were moderate, but excellent enantioselectivities were obtained for both diastereomers (79-94% ee).
منابع مشابه
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 29 شماره
صفحات -
تاریخ انتشار 2012